Three-dimensional bioprinting of patient-derived Gastrointestinal stromal tumor: a novel platform for precision oncology and drug response profiling
Liwei Du, Zicheng Zheng, Yanan Wang, Kai Zhang, Yuce Lu, Minghao Sun, Mingchang Pang, Shangze Jiang, Yixuan He, Shunda Du, Haitao Zhao, Yilei Mao, Huayu Yang, Weiming Kang · 2025
Read Three-dimensional bioprinting of patient-derived Gastrointestinal stromal tumor: a novel platform for precision oncology and drug response profiling by Liwei Du, Zicheng Zheng, Yanan Wang, Kai Zhang, Yuce Lu, Minghao Sun, Mingchang Pang, Shangze Jiang, Yixuan He, Shunda Du, Haitao Zhao, Yilei Mao, Huayu Yang, Weiming Kang (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12831436.txt.
Description
Liwei Du and co-authors printed living tumor models from patients' own cancer cells in this 2025 study. The tumors are gastrointestinal stromal tumors, which vary widely from person to person. Flat cell cultures cannot copy a tumor's inner layout, so drug tests on them often mislead.
The team bioprinted twelve patient-derived models in three dimensions. Gene and tissue checks showed the prints kept the look and molecular marks of the real tumors. Gene patterns tied to relapse and drug resistance showed up as well. The researchers then dosed the prints with approved targeted drugs and matched the responses against the patients' own records. The platform could help pick the right drug per patient.
Catalog record
| CREATOR | Liwei Du, Zicheng Zheng, Yanan Wang, Kai Zhang, Yuce Lu, Minghao Sun, Mingchang Pang, Shangze Jiang, Yixuan He, Shunda Du, Haitao Zhao, Yilei Mao, Huayu Yang, Weiming Kang |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 71 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |