Fatty acid binding protein 4 induces osteogenesis and angiogenesis as pathogenesis of metabolic osteoarthritis
Chaofan Zhang, Yinjun Mao, Yishan Xin, Hongyan Li, Maocan Cai, Yiming Lin, Xuehui Zhang, Ying Huang, Yang Chen, Zida Huang, Xinyu Fang, Wenming Zhang, Yunzhi Lin · 2025
Read Fatty acid binding protein 4 induces osteogenesis and angiogenesis as pathogenesis of metabolic osteoarthritis by Chaofan Zhang, Yinjun Mao, Yishan Xin, Hongyan Li, Maocan Cai, Yiming Lin, Xuehui Zhang, Ying Huang, Yang Chen, Zida Huang, Xinyu Fang, Wenming Zhang, Yunzhi Lin (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12831317.txt.
Description
Chaofan Zhang and co-authors study a fat-handling protein, FABP4, as a driver of metabolic osteoarthritis. Their 2025 paper asks how this protein helps damage joints in animals fed a rich diet. The broad causes of osteoarthritis are still not fully known, and the metabolic form is especially murky.
Mice lacking the protein, and normal mice given a drug that blocks it, were fed a high-fat diet for months. Both protected groups showed less bone hardening under the cartilage and fewer of a special vessel type tied to new bone growth. In cell tests, the protein pushed stem cells toward bone formation through a growth pathway. It also aided vessel growth, tying fat signals to joint change.
Catalog record
| CREATOR | Chaofan Zhang, Yinjun Mao, Yishan Xin, Hongyan Li, Maocan Cai, Yiming Lin, Xuehui Zhang, Ying Huang, Yang Chen, Zida Huang, Xinyu Fang, Wenming Zhang, Yunzhi Lin |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 49 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |