Combined action of suicide gene exosomes from pancreatic cancer-associated fibroblasts and from mesenchymal stem cells as a pancreatic ductal adenocarcinoma treatment approach
Jana Jakubechova, Ursula Altanerova, Michal Andrezal, Dajana Vanova, Tatiana Zeleznikova, Peter Bartek, Marina Cihova, Bozena Smolkova, Verona Buocikova, Peter Makovicky, Kristina Jakic, Monika Burikova, Maria Urbanova, Veronika Repaska, Benjamin Spanik, Miroslav Tomas, Peter Dubovan, Georgina Kolni · 2025
Read Combined action of suicide gene exosomes from pancreatic cancer-associated fibroblasts and from mesenchymal stem cells as a pancreatic ductal adenocarcinoma treatment approach by Jana Jakubechova, Ursula Altanerova, Michal Andrezal, Dajana Vanova, Tatiana Zeleznikova, Peter Bartek, Marina Cihova, Bozena Smolkova, Verona Buocikova, Peter Makovicky, Kristina Jakic, Monika Burikova, Maria Urbanova, Veronika Repaska, Benjamin Spanik, Miroslav Tomas, Peter Dubovan, Georgina Kolni (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12831315.txt.
Description
Pancreatic cancer wraps itself in scar tissue that drugs cannot cross, so Jana Jakubechova and co-authors smuggle the weapon inside the scar's own mail in a 2025 paper. The mail is exosomes, tiny vesicles shed by cells. The team loaded exosomes from the tumor's own fibroblasts, and from mesenchymal stem cells, with a suicide gene.
The gene, borrowed from yeast, turns a harmless prodrug into a killer once inside a cell. Both cell types were engineered to secrete the loaded vesicles steadily, and the products were profiled by physical, chemical, and proteomic methods. Tumor-killing tests followed. The authors' logic is targeting by origin: vesicles born from the tumor's support cells should home back to the tumor's neighborhood, carrying a gene that makes the recipient destroy itself on cue.
Catalog record
| CREATOR | Jana Jakubechova, Ursula Altanerova, Michal Andrezal, Dajana Vanova, Tatiana Zeleznikova, Peter Bartek, Marina Cihova, Bozena Smolkova, Verona Buocikova, Peter Makovicky, Kristina Jakic, Monika Burikova, Maria Urbanova, Veronika Repaska, Benjamin Spanik, Miroslav Tomas, Peter Dubovan, Georgina Kolni |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 57 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |