Structural basis for genome-wide site-specific DNA recognition by Nuclear Factor IA
Ci Zhu, Ding Xiao, Zhipu Luo, Jie Zhang, Shuang Liu, Yueyu Wang, Xi Chen, Hejin Xiao, Xiaofeng Li, Juyu Tang, Xianyang Fang, Jie Shen, He Song · 2025
Read Structural basis for genome-wide site-specific DNA recognition by Nuclear Factor IA by Ci Zhu, Ding Xiao, Zhipu Luo, Jie Zhang, Shuang Liu, Yueyu Wang, Xi Chen, Hejin Xiao, Xiaofeng Li, Juyu Tang, Xianyang Fang, Jie Shen, He Song (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12830966.txt.
Description
Ci Zhu and co-authors work out how a DNA binding protein reads its target sites, in a 2025 study. The protein, Nuclear Factor IA, guides growth and metabolism, and its loss is tied to brain defects in people. Past work held that two copies join to grip a paired DNA motif, but that model was unsettled.
The team shows the protein sits alone in solution, both whole and as its binding part alone. Genome wide maps show half sites, not just pairs, are common in its targets. Crystal and solution shapes of the protein on both kinds of site back the solo reading. Key contact points proved vital in binding tests.
Catalog record
| CREATOR | Ci Zhu, Ding Xiao, Zhipu Luo, Jie Zhang, Shuang Liu, Yueyu Wang, Xi Chen, Hejin Xiao, Xiaofeng Li, Juyu Tang, Xianyang Fang, Jie Shen, He Song |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |