A Plug-in system for reprogramming the editing patterns of base editors
Chaoyue Zhong, Lan Yu, Tingting Zhao, Xue Shen, Zhen Li, Wei Zhu, Zheng Hu, Rui Tian, Zhiqiang Han, Dan He · 2025
Read A Plug-in system for reprogramming the editing patterns of base editors by Chaoyue Zhong, Lan Yu, Tingting Zhao, Xue Shen, Zhen Li, Wei Zhu, Zheng Hu, Rui Tian, Zhiqiang Han, Dan He (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12830782.txt.
Description
Chaoyue Zhong and co-authors make gene editors more flexible in this 2025 paper. Base editors swap single DNA letters without cutting both strands, a safer path to fix gene faults. Their reach is boxed in by fixed edit zones and set enzyme spots, though.
The team's plug-in design steers the enzyme with tag-and-catcher pairs that can be swapped at will. Moving the enzyme reshapes the edit zone and lifts both yield and safety in their tests. The system proved its worth in cancer gene work and in fish embryo edits. Since new editors can be built by swapping parts, the authors say the design skips long enzyme reshaping work.
Catalog record
| CREATOR | Chaoyue Zhong, Lan Yu, Tingting Zhao, Xue Shen, Zhen Li, Wei Zhu, Zheng Hu, Rui Tian, Zhiqiang Han, Dan He |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 56 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |