PLAUR, C3, and EMP3 coordinate tumor progression and immune evasion in clear cell renal cell carcinoma
S. R. Zi, Z. Y. Feng, L. S. Dong · 2025
Read PLAUR, C3, and EMP3 coordinate tumor progression and immune evasion in clear cell renal cell carcinoma by S. R. Zi, Z. Y. Feng, L. S. Dong (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12830536.txt.
Description
Zi, Feng, and Dong wrote this 2025 paper on three genes that drive kidney cancer growth and help it hide from the immune system. The cancer is clear cell renal cell carcinoma, the most common kind of kidney cancer. Its course is tied closely to the tissue around the tumor and to immune evasion.
The team mined two public gene data sets for genes whose activity differed in tumors. A network method then grouped genes that rise and fall together and linked the groups to clinical traits. Enrichment and survival analyses pointed to three hub genes: PLAUR, C3, and EMP3. Single-cell data showed which cells make them. Lab tests, from gene measures to wound healing assays, checked their roles. The authors present the trio as candidate markers for diagnosis and as targets for new therapy.
Catalog record
| CREATOR | S. R. Zi, Z. Y. Feng, L. S. Dong |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |