Enhanced anti-liver tumor efficacy of chimeric antigen receptor-T cells via SATB1 modulation
Lin Zhang, Chenxi Cheng, Xinyi Bi, Jiani Cao, Xiaoyan Li, Tongbiao Zhao · 2025
Read Enhanced anti-liver tumor efficacy of chimeric antigen receptor-T cells via SATB1 modulation by Lin Zhang, Chenxi Cheng, Xinyi Bi, Jiani Cao, Xiaoyan Li, Tongbiao Zhao (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12830387.txt.
Description
Lin Zhang and co-authors boost engineered immune cells against liver cancer in this 2025 study. CAR-T therapy shines in blood cancers but fades in solid tumors, as the cells tire out inside hostile tumor tissue. The team found a genome organizer protein, SATB1, runs low in tired tumor-invading cells.
Raising SATB1 in liver-targeted CAR-T cells cut several brake receptors at once. The cells also kept a long-lived memory form, made more killer signals, and killed liver cancer cells better in dishes. In mice the boosted cells controlled tumors and extended survival. The authors offer SATB1 tuning as a fitness upgrade for solid tumor therapy.
Catalog record
| CREATOR | Lin Zhang, Chenxi Cheng, Xinyi Bi, Jiani Cao, Xiaoyan Li, Tongbiao Zhao |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 40 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |