Preclinical validation of a clinical prototype of intraoperative electron FLASH radiotherapy equipment: key evidence for a new radiotherapy paradigm
Xiaofei Hao, Huan Du, Binwei Lin, Yang Xia, Mingming Tang, Wei Wu, Decai Wang, Yihan Zhu, Yu Zhang, Jianxin Wang, Yiwei Yang, Dai Wu, Xiaobo Du · 2025
Read Preclinical validation of a clinical prototype of intraoperative electron FLASH radiotherapy equipment: key evidence for a new radiotherapy paradigm by Xiaofei Hao, Huan Du, Binwei Lin, Yang Xia, Mingming Tang, Wei Wu, Decai Wang, Yihan Zhu, Yu Zhang, Jianxin Wang, Yiwei Yang, Dai Wu, Xiaobo Du (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12829257.txt.
Description
Xiaofei Hao and co-authors put a surgical radiation prototype through its first full animal tests. Their 2025 study covers FLASH radiotherapy, which delivers a whole dose in a flash of ultra-high rate, aiming to spare healthy tissue while still killing tumors.
The machine, built for use during surgery, reached rates far above the FLASH threshold at working distance. In mice carrying breast, brain, and pancreatic tumors, the flash matched standard radiation at shrinking tumors. Healthy animals told the real story: flash-treated mice kept better memory after brain doses, survived better after chest and belly doses, and showed milder lung, gut, and skin injury. The authors call for clinical trials of the device.
Catalog record
| CREATOR | Xiaofei Hao, Huan Du, Binwei Lin, Yang Xia, Mingming Tang, Wei Wu, Decai Wang, Yihan Zhu, Yu Zhang, Jianxin Wang, Yiwei Yang, Dai Wu, Xiaobo Du |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |