Interactions between Plasmodium falciparum–infected red blood cells and their extracellular vesicles with megakaryocytes: implications for platelet-like particle formation
Nuntiporn Nunthanasup, Attakorn Palasuwan, Duangdao Palasuwan, Valery Combes · 2025
Read Interactions between Plasmodium falciparum–infected red blood cells and their extracellular vesicles with megakaryocytes: implications for platelet-like particle formation by Nuntiporn Nunthanasup, Attakorn Palasuwan, Duangdao Palasuwan, Valery Combes (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12829250.txt.
Description
Nuntiporn Nunthanasup, Attakorn Palasuwan, Duangdao Palasuwan, and Valery Combes published this 2025 study on why malaria drains the blood of platelets. Low counts are a hallmark of falciparum malaria, yet what happens at the platelet factory, the megakaryocyte, was murky. The team grew a human cell line of that kind beside infected red blood cells and the vesicles they shed.
Infected cells clung briefly to the growing cells, then suppressed their maturation markers and changed stress and death genes, turning NOTCH3 down. Platelet-like particles were made in greater numbers under some conditions, but they clotted poorly. The shed vesicles, by contrast, slipped inside cells yet changed little. The picture is plain: the infected cells themselves block new platelets at the source.
Catalog record
| CREATOR | Nuntiporn Nunthanasup, Attakorn Palasuwan, Duangdao Palasuwan, Valery Combes |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 64 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |