Plasma untargeted metabolomics reveals the metabolic landscape of NKTCL and aids in liquid biopsy for disease detection
Siyu Qian, Yue Zhang, Mingzhi Zhang, Qingjiang Chen, Xudong Zhang · 2025
Read Plasma untargeted metabolomics reveals the metabolic landscape of NKTCL and aids in liquid biopsy for disease detection by Siyu Qian, Yue Zhang, Mingzhi Zhang, Qingjiang Chen, Xudong Zhang (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12829221.txt.
Description
Qian and co-authors map chemical changes in the blood of patients with NK/T-cell lymphoma. Shifts in cell metabolism are a known mark of this cancer, but the full blood picture was unclear. The team used a broad, untargeted scan of plasma from 92 patients and 28 healthy controls. The method paired liquid chromatography with high-resolution mass spectrometry.
Blood profiles differed clearly between patients and healthy people. The changed compounds clustered in purine, arginine, proline, and pyrimidine pathways. Three compounds were combined into a test model with good diagnostic performance. The authors suggest such a blood test could aid early, non-invasive screening for the disease. More work would be needed before clinic use.
Catalog record
| CREATOR | Siyu Qian, Yue Zhang, Mingzhi Zhang, Qingjiang Chen, Xudong Zhang |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 23 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |