RNF152-mediated, ubiquitin-dependent degradation of HSP27 activates the PI3K/AKT pathway, driving synovial inflammatory cascades in TMJOA
Xinjian Zhang, Qingkun Jiang, Wei Deng, Hai Tang, Yang Liu, Zichen Xu, Ke Guo, Ning Liu, Haitao Wang, Tiehan Cui, Fang Wang, Jiaxuan Qiu · 2025
Read RNF152-mediated, ubiquitin-dependent degradation of HSP27 activates the PI3K/AKT pathway, driving synovial inflammatory cascades in TMJOA by Xinjian Zhang, Qingkun Jiang, Wei Deng, Hai Tang, Yang Liu, Zichen Xu, Ke Guo, Ning Liu, Haitao Wang, Tiehan Cui, Fang Wang, Jiaxuan Qiu (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12829216.txt.
Description
Xinjian Zhang and co-authors traced a chain of protein events that fuels joint inflammation in the jaw, in work published in 2025. The disease, jaw joint osteoarthritis, wears down the hinge that moves the lower jaw. The team hunted for enzymes that switch on the lining cells of the joint and drive damage. Gene scans of stressed lining cells pointed to one enzyme, called RNF152.
Tests showed the enzyme tags a protective protein, HSP27, for destruction inside the cell. Losing that guard switches on a growth pathway that makes lining cells multiply and release inflammatory signals. In rats with the disease, silencing the enzyme in the joint eased lining overgrowth and cartilage harm. The authors propose the enzyme-to-protein chain as a fresh target for drugs against this painful jaw disease.
Catalog record
| CREATOR | Xinjian Zhang, Qingkun Jiang, Wei Deng, Hai Tang, Yang Liu, Zichen Xu, Ke Guo, Ning Liu, Haitao Wang, Tiehan Cui, Fang Wang, Jiaxuan Qiu |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 56 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |