A positive feedback loop between KPNA2 and FOXM1 promotes the proliferation of lung adenocarcinoma
Ying Wang, Yan Jin, Xin Li · 2025
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Description
Ying Wang, Yan Jin, and Xin Li found a self feeding loop that drives lung adenocarcinoma growth. Their study, from twenty twenty-five, deals with a common form of lung cancer. It makes up a large share of all lung cases, yet survival stays poor. Fresh targets are needed. The team first cut a gene, KPNA2, in cancer cell lines and read how growth changed with two lab tests.
A known switch, FOXM1, was shown to bind the start zone of that gene. Model folds then guessed which proteins bind the gene's product. The two drive each other in a loop that feeds cell growth. Readers get a loop whose break could slow this cancer.
Catalog record
| CREATOR | Ying Wang, Yan Jin, Xin Li |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 28 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |