Exploring the biliary microbiome in hepatopancreatobiliary disorders: a comprehensive systematic review of microbial signatures and diagnostic potential
Hossein Halimi, Zeinab Hesami, Nastaran Asri, Babak Khorsand, Mohammad Rostami-Nejad, Hamidreza Houri · 2025
Read Exploring the biliary microbiome in hepatopancreatobiliary disorders: a comprehensive systematic review of microbial signatures and diagnostic potential by Hossein Halimi, Zeinab Hesami, Nastaran Asri, Babak Khorsand, Mohammad Rostami-Nejad, Hamidreza Houri (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12829193.txt.
Description
Hossein Halimi and co-authors review what microbes live in bile and how their patterns shift across liver, gallbladder, and pancreas diseases, in a 2025 systematic review. The bile duct tree was once thought sterile, but gene sequencing now finds resident bacteria. The team screened the literature under standard review rules and kept 24 studies that sequenced bile microbes in four conditions.
Each disease carried its own microbial signature. Stones that kept returning, or grew giant, tracked with two bacterial genera. A phylum called Proteobacteria dominated in a bile duct scarring disease and in bile duct cancer, where it may feed chronic inflammation. One genus appeared in both cancers and the scarring disease, and linked to spread in pancreatic cancer. The authors see diagnostic promise but warn that methods vary and healthy controls are few.
Catalog record
| CREATOR | Hossein Halimi, Zeinab Hesami, Nastaran Asri, Babak Khorsand, Mohammad Rostami-Nejad, Hamidreza Houri |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 92 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |