PISTOL MRI allows noninvasive assessment of changes in tumor oxygenation post hypoxia targeted therapy
Shubhangi Agarwal, Lakshmisree Damodaran, Landon J Inge, Vikram D Kodibagkar · 2025
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Description
Shubhangi Agarwal and co-authors image tumor oxygen without a needle in a 2025 study. Low oxygen helps tumors grow and resist radiation and drugs, and it marks a poor outlook. Drugs exist that wake up only in low-oxygen tissue. The team used an MRI method called PISTOL, which reads oxygen levels from a silicone-based signal.
Two tumor types in lab models were scanned before and after one such drug. One type started less oxygenated than the other. Yet the drug slowed growth only in the better-oxygenated type, where it also cut oxygen further in the tumor core and raised fluid content. The less-oxygenated tumors did not respond. Imaging oxygen before treatment may help predict which tumors such drugs can actually help.
Catalog record
| CREATOR | Shubhangi Agarwal, Lakshmisree Damodaran, Landon J Inge, Vikram D Kodibagkar |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 40 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |