Transcriptomic signatures in brain and blood related to cognitive and psychiatric phenotypes of Prader–Willi syndrome
Shokouh Shahrokhi, Emma K Baker, Michael See, Mirana Ramialison, Dinusha Gamage, Fernando J Rossello, Helen Heussler, Michael Duhig, Robert D Nicholls, Anthony J Hannan, Melissa C Southey, Olivia Veatch, Waheeda Hossain, Minh Bui, David J Amor, Merlin G Butler, David E Godler · 2025
Read Transcriptomic signatures in brain and blood related to cognitive and psychiatric phenotypes of Prader–Willi syndrome by Shokouh Shahrokhi, Emma K Baker, Michael See, Mirana Ramialison, Dinusha Gamage, Fernando J Rossello, Helen Heussler, Michael Duhig, Robert D Nicholls, Anthony J Hannan, Melissa C Southey, Olivia Veatch, Waheeda Hossain, Minh Bui, David J Amor, Merlin G Butler, David E Godler (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12827965.txt.
Description
Shokouh Shahrokhi and co-authors read gene activity in brain and blood from people with Prader-Willi syndrome, in a 2025 study. The syndrome affects learning, mood, and behavior. The team asked which gene changes in the brain's front region track those traits. They also asked whether blood carries the same signals.
Brain tissue came from eight donors with the syndrome and four matched donors without it. A method that reads single cell nuclei covered thousands of genes. One cell type, interneurons, made up a larger share in the syndrome group. Fifty-four genes were off-pattern across all cell types. One protein-coding gene was raised in every comparison. Blood links could one day ease testing.
Catalog record
| CREATOR | Shokouh Shahrokhi, Emma K Baker, Michael See, Mirana Ramialison, Dinusha Gamage, Fernando J Rossello, Helen Heussler, Michael Duhig, Robert D Nicholls, Anthony J Hannan, Melissa C Southey, Olivia Veatch, Waheeda Hossain, Minh Bui, David J Amor, Merlin G Butler, David E Godler |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |