Clinical course, risk factors and mitigating strategies for Immune effector cell-associated late onset neurotoxicities after ciltacabtagene autoleucel CAR-T in multiple myeloma
Kenneth J. C. Lim, Melinda Tan, Ricardo Parrondo, Saurabh Chhabra, Katharine Dooley, Andre De Menezes Silva Corraes, Darin Carabenciov, Morie Gertz, Lisa Hwa, Stephens Haily, Prashant Kapoor, Taxiarchis Kourelis, Rahma Warsame, Joselle Cook, Moritz Binder, P. Leif Bergsagel, Udit Yadav, Erin Wiedmei · 2025
Read Clinical course, risk factors and mitigating strategies for Immune effector cell-associated late onset neurotoxicities after ciltacabtagene autoleucel CAR-T in multiple myeloma by Kenneth J. C. Lim, Melinda Tan, Ricardo Parrondo, Saurabh Chhabra, Katharine Dooley, Andre De Menezes Silva Corraes, Darin Carabenciov, Morie Gertz, Lisa Hwa, Stephens Haily, Prashant Kapoor, Taxiarchis Kourelis, Rahma Warsame, Joselle Cook, Moritz Binder, P. Leif Bergsagel, Udit Yadav, Erin Wiedmei (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12827462.txt.
Description
Kenneth Lim leads a large team in a 2025 study of late nerve side effects after a CAR-T cell therapy for multiple myeloma. The therapy, called cilta-cel, is used in standard care for patients whose cancer has come back or stopped responding to other drugs.
Among more than two hundred patients, a small share got late nerve palsies and a smaller share got a parkinsonism-like syndrome. The team tracks how each case ran, what signs came first, and which traits raised the risk. Older age and a high load of plasma cells in the marrow stood out before the infusion.
Catalog record
| CREATOR | Kenneth J. C. Lim, Melinda Tan, Ricardo Parrondo, Saurabh Chhabra, Katharine Dooley, Andre De Menezes Silva Corraes, Darin Carabenciov, Morie Gertz, Lisa Hwa, Stephens Haily, Prashant Kapoor, Taxiarchis Kourelis, Rahma Warsame, Joselle Cook, Moritz Binder, P. Leif Bergsagel, Udit Yadav, Erin Wiedmei |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 50 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |