Dysregulated hippocampal fatty acid metabolism following intermittent hypoxemia-induced neonatal brain injury is rescued by treatment with acetate
Regina F Fernandez, Wedad Fallatah, Yuanyuan Ji, Jace W Jones, Cole C Johnson, Caitlin M Tressler, Kristine Glunde, Rida Ali, Ann B Moser, Michael J Wolfgang, Susanna Scafidi, Joseph Scafidi · 2025
Read Dysregulated hippocampal fatty acid metabolism following intermittent hypoxemia-induced neonatal brain injury is rescued by treatment with acetate by Regina F Fernandez, Wedad Fallatah, Yuanyuan Ji, Jace W Jones, Cole C Johnson, Caitlin M Tressler, Kristine Glunde, Rida Ali, Ann B Moser, Michael J Wolfgang, Susanna Scafidi, Joseph Scafidi (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12827289.txt.
Description
Regina Fernandez and co-authors show that a simple fuel rescues fat metabolism in the injured newborn brain. Their 2025 study models the intermittent low oxygen that injures extremely preterm infants. The developing brain is fat-rich and builds lipids furiously after birth, yet how injury scrambles that chemistry was little understood. The team focused on the hippocampus, the memory center whose damage drives later cognitive problems.
Injured animals showed a distorted hippocampal fat profile and an unexpected rise in mitochondrial fat burning, a process the developing brain barely uses. Supplying acetate, an alternative fuel, spared fatty acids from that burning. Given as a supplement in life, acetate restored the fat profile and promoted functional recovery. The work suggests nutrition can patch a specific metabolic wound.
Catalog record
| CREATOR | Regina F Fernandez, Wedad Fallatah, Yuanyuan Ji, Jace W Jones, Cole C Johnson, Caitlin M Tressler, Kristine Glunde, Rida Ali, Ann B Moser, Michael J Wolfgang, Susanna Scafidi, Joseph Scafidi |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 94 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |