Microbial metabolite 5-formamidoimidazole-4-carboxamide ribotide targets METTL1 to inhibit m7G modification of BRCA1 mRNA to inhibit high-grade serous ovarian cancer
Lixing Chen, Sili He · 2025
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Description
Lixing Chen and Sili He report a 2025 study on a severe form of ovarian cancer. The work links vaginal microbes, a compound they make, and two genes in tumor cells. In the cancer, both genes were raised. One gene helped lift the other, and that change sped cell growth and tumor growth in mice.
Tests showed the microbe compound binds well to the first gene's protein. The compound then blocked the gene link, slowed cell growth, and shrank tumor growth. When either gene was forced high, the benefit was lost. The findings suggest a new route to treat this cancer, based on a compound from normal microbes. More work must test safety in people.
Catalog record
| CREATOR | Lixing Chen, Sili He |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 62 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |