Long non-coding RNAs in the tumor immune microenvironment of non-small cell lung cancer: mechanisms and clinical translational perspectives
Weiwei Wang, Zhibiao Jiang, Kun Zhao, Yuanyin Teng, Lingling Wu, Ting Yu, Anquan Shang · 2025
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Description
Weiwei Wang and co-authors wrote this 2025 review on long non-coding RNAs in the immune surroundings of lung cancer. These long RNA strands do not build proteins, yet they steer many cell programs. In non-small cell lung cancer, they help shape an immune landscape that often resists checkpoint drugs.
The review maps how named strands tilt immune evasion through the PD-1 pathway, guide T cell survival, and set macrophage behavior. Others tie into iron-driven cell death, stemness, and fuel rewiring. A handful of strands already forecast survival or drug response in patients. Strands shipped in tiny blood vesicles could serve as painless biopsy tools. The authors weigh RNA drugs, delivery systems, and drug pairings as the road to the clinic.
Catalog record
| CREATOR | Weiwei Wang, Zhibiao Jiang, Kun Zhao, Yuanyin Teng, Lingling Wu, Ting Yu, Anquan Shang |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 55 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |