Probing the activity of cysteine cathepsins in inflammatory bowel diseases
Bethany M Anderson, Alexander R Ziegler, Rhiannon I Campden, Hongyi Wu, Bangyan Xu, Rachel M McQuade, Simona E Carbone, Daniel P Poole, Alan E Lomax, David E Reed, Stephen J Vanner, Robin M Yates, Nigel W Bunnett, Laura E Edgington-Mitchell · 2025
Read Probing the activity of cysteine cathepsins in inflammatory bowel diseases by Bethany M Anderson, Alexander R Ziegler, Rhiannon I Campden, Hongyi Wu, Bangyan Xu, Rachel M McQuade, Simona E Carbone, Daniel P Poole, Alan E Lomax, David E Reed, Stephen J Vanner, Robin M Yates, Nigel W Bunnett, Laura E Edgington-Mitchell (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12824247.txt.
Description
Bethany Anderson and co-authors probe enzyme activity in bowel disease in a 2025 study. Cathepsins are enzymes that cut proteins, and one of them, cathepsin S, has been tied to gut pain in inflammatory bowel disease. The team asked whether it drives other symptoms too.
Using activity probes in human samples and mouse colitis, they found cathepsin S raised sharply in stool and gut fluid during disease, though not in gut tissue itself. Mice lacking the enzyme bled less and had milder tissue scores, but most other signs stayed alike. A drug blocking the enzyme gave mixed effects. The work maps where these enzymes act in the inflamed gut.
Catalog record
| CREATOR | Bethany M Anderson, Alexander R Ziegler, Rhiannon I Campden, Hongyi Wu, Bangyan Xu, Rachel M McQuade, Simona E Carbone, Daniel P Poole, Alan E Lomax, David E Reed, Stephen J Vanner, Robin M Yates, Nigel W Bunnett, Laura E Edgington-Mitchell |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |