In vitro and in silico evaluation of flavonoids from Erythrina crista-galli with cytotoxic potential against MCF-7 breast cancer cell
Tati Herlina, Melati Sukma, Abd. Wahid Rizaldi Akili, Ari Hardianto, Jalifah Latip, Euis Julaeha, Tri Mayanti · 2025
Read In vitro and in silico evaluation of flavonoids from Erythrina crista-galli with cytotoxic potential against MCF-7 breast cancer cell by Tati Herlina, Melati Sukma, Abd. Wahid Rizaldi Akili, Ari Hardianto, Jalifah Latip, Euis Julaeha, Tri Mayanti (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12824246.txt.
Description
Flavonoids from plants are studied as possible cancer drugs because they can hit several targets at once. The authors isolate three flavonoids from the twigs of Erythrina crista-galli, a flowering tree, and test them on MCF-7 breast cancer cells. Lab assays measure how strongly each compound slows the cells. Computer docking and dynamics simulations then examine how the best compound binds the epidermal growth factor receptor, a known cancer target.
Two compounds, naringenin and isoliquiritigenin, show moderate activity, while daidzein is weak. Isoliquiritigenin binds the receptor more strongly than ATP in docking, and the simulated complex stays stable, with a favorable binding energy. A network analysis links the compound to several breast cancer targets, with that receptor as a hub. The authors name isoliquiritigenin a promising lead, while stressing that animal tests and toxicity checks still lie ahead.
Catalog record
| CREATOR | Tati Herlina, Melati Sukma, Abd. Wahid Rizaldi Akili, Ari Hardianto, Jalifah Latip, Euis Julaeha, Tri Mayanti |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |