Multiomics insight into disease trajectories of cardiometabolic diseases and cancer
Xuanwei Jiang, Guangrui Yang, Meng Chen, Nannan Feng, Lan Xu, Xihao Du, Chunlai Zeng, Victor W Zhong · 2025
Read Multiomics insight into disease trajectories of cardiometabolic diseases and cancer by Xuanwei Jiang, Guangrui Yang, Meng Chen, Nannan Feng, Lan Xu, Xihao Du, Chunlai Zeng, Victor W Zhong (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12824212.txt.
Description
Xuanwei Jiang and co-authors present a 2025 study of how heart-metabolic diseases and cancer combine. Having both is rising as populations age, yet the paths into that state were unmapped. The team follows 429,555 UK Biobank participants for a median of fifteen years. About 106,000 develop a single disease, and about 15,000 develop the combined state. Multi-state models chart the order in which diseases arrive. Blood and molecular profiles are layered onto the paths.
People with both disease families die at rates thirteen to thirty-three percent higher than others. Order matters: heart-metabolic disease first, then cancer, is deadlier than the reverse. Protein scores predict the paths better than other molecular layers. Clinicians get a trajectory map for patients collecting chronic diseases. Prediction models built on proteins could flag who heads for the combined state. The order effect tells follow-up clinics where to watch hardest.
Catalog record
| CREATOR | Xuanwei Jiang, Guangrui Yang, Meng Chen, Nannan Feng, Lan Xu, Xihao Du, Chunlai Zeng, Victor W Zhong |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 66 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |