AP-1 elements in the promoter and second intron mediate endoplasmic reticulum stress-induced expression of the GPAT3 gene
Daima Örd, Tiit Örd, Elina Gluboki, Tõnis Örd · 2025
Read AP-1 elements in the promoter and second intron mediate endoplasmic reticulum stress-induced expression of the GPAT3 gene by Daima Örd, Tiit Örd, Elina Gluboki, Tõnis Örd (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12824169.txt.
Description
Daima Örd, Tiit Örd, Elina Gluboki, and Tõnis Örd wrote this 2025 paper on how cell stress switches on a fat-making gene. Fatty liver disease and its severe form are marked by excess fat in the liver. The gene GPAT3 helps build glycerolipids, the backbone of stored fat, and its activity runs high in patients with the severe disease.
The team studied human liver tumor cells under endoplasmic reticulum stress, a strain state tied to the disease. A gene scan showed GPAT3 among the most strongly switched-on fat genes when stress was induced. Knocking out a stress factor called ATF4 with gene editing cut that response. The authors trace the switch to AP-1 elements in the gene's promoter and in its second intron. Those DNA sites pass the stress signal into gene action.
Catalog record
| CREATOR | Daima Örd, Tiit Örd, Elina Gluboki, Tõnis Örd |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |