Characterization of T cell markers in endometrial carcinoma through single-cell RNA sequencing
Menghuang Zhao, Lulu Zhou · 2025
Read Characterization of T cell markers in endometrial carcinoma through single-cell RNA sequencing by Menghuang Zhao, Lulu Zhou (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12824090.txt.
Description
Menghuang Zhao and Lulu Zhou build a prognosis score for womb cancer from the genes of its T cells, in a 2025 study. Endometrial carcinoma is a leading cancer of the female reproductive tract, and advanced cases do poorly. Immunotherapy helps some patients, and T cells are the immune system's main cancer fighters.
Mining single-cell data, the authors identified marker genes defining the tumor's T cells. They then trained an eight-gene signature on bulk data from five hundred forty-four patients. The score predicted five-year survival with good accuracy and tracked immune activity in the tumor. It also carried signals about likely responses to immunotherapy and chemotherapy, and about mutation patterns. A T-cell-based score could help clinicians sort patients toward the treatments likeliest to work.
Catalog record
| CREATOR | Menghuang Zhao, Lulu Zhou |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 33 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |