Ligand non-competitive GITR antibody prevents formation of the obligatory signal-triggering GITRL: GITR stoichiometry
Jing Yan, Jessica Min-DeBartolo, Ching-Shin Huang, M. Nusrat Sharif, Li Li, Susan Fish, Corey Dower, Denise Murphy, Tatyana Andreyeva, Heng Liu, Xinbing Han, Wei Zheng, Jot Hui Ooi, Jason Edmonds, Ting Chen, Zachary Maben, Chad R. Stevens, Polina Goihberg, Malgorzata Nocula-Lugowska, Steven M Evans, · 2025
Read Ligand non-competitive GITR antibody prevents formation of the obligatory signal-triggering GITRL: GITR stoichiometry by Jing Yan, Jessica Min-DeBartolo, Ching-Shin Huang, M. Nusrat Sharif, Li Li, Susan Fish, Corey Dower, Denise Murphy, Tatyana Andreyeva, Heng Liu, Xinbing Han, Wei Zheng, Jot Hui Ooi, Jason Edmonds, Ting Chen, Zachary Maben, Chad R. Stevens, Polina Goihberg, Malgorzata Nocula-Lugowska, Steven M Evans, (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12823560.txt.
Description
Jing Yan and co-authors describe a new antibody that calms an overactive immune signal, in this 2025 paper. The target is GITR, a switch on immune cells whose trigger drives diseases such as bowel inflammation and rheumatoid arthritis. Many past antibodies accidentally turned the switch on instead of off, which stalled the field.
Their antibody binds without competing with the natural trigger, yet blocks the signal by breaking up the larger structures the switch must form. It silenced the pathway in lab tests. It did not help in one transplant model, but the authors argue the trick could work for related immune switches that rely on loose triggers.
Catalog record
| CREATOR | Jing Yan, Jessica Min-DeBartolo, Ching-Shin Huang, M. Nusrat Sharif, Li Li, Susan Fish, Corey Dower, Denise Murphy, Tatyana Andreyeva, Heng Liu, Xinbing Han, Wei Zheng, Jot Hui Ooi, Jason Edmonds, Ting Chen, Zachary Maben, Chad R. Stevens, Polina Goihberg, Malgorzata Nocula-Lugowska, Steven M Evans, |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 61 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |