Dysbiosis of the gut microbiota in calcium oxalate nephrolithiasis is associated with impaired short-chain fatty acid production and systemic metabolomic disruptions
Xi Chen, Fangxing Zhang, Lang Cheng, Decao Niu, Jianpei Hu, Shengzhu Huang, Fubo Wang, Guijian Pang, Caisheng Huang, Mingli Li, Chao Wang, Zengnan Mo · 2025
Read Dysbiosis of the gut microbiota in calcium oxalate nephrolithiasis is associated with impaired short-chain fatty acid production and systemic metabolomic disruptions by Xi Chen, Fangxing Zhang, Lang Cheng, Decao Niu, Jianpei Hu, Shengzhu Huang, Fubo Wang, Guijian Pang, Caisheng Huang, Mingli Li, Chao Wang, Zengnan Mo (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12822354.txt.
Description
Xi Chen and eleven co-workers wrote a 2025 study on gut microbes in people who form calcium oxalate kidney stones. Such stones are growing more common, and their causes are not fully clear. Bacteria that make short fatty acids may sway body chemistry toward or away from stones. The team compared stone formers with healthy peers.
Stone formers held fewer kinds of gut microbes, with key acid makers depleted. Their stool and blood held lower levels of those acids, and their urine held less citrate. Blood acid levels tracked with urine citrate in their data. A gene-based check flagged one bacterium as a possible risk factor. Rat tests added support.
Catalog record
| CREATOR | Xi Chen, Fangxing Zhang, Lang Cheng, Decao Niu, Jianpei Hu, Shengzhu Huang, Fubo Wang, Guijian Pang, Caisheng Huang, Mingli Li, Chao Wang, Zengnan Mo |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 73 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |