Aging-associated transcriptional programs in T cells signify constituents of TGF-β signaling for immunosenescence
Renke He, Chanchan Xiao, Wen Lei, Guobing Chen, Yangqiu Li, Oscar Junhong Luo · 2025
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Description
Six researchers led by Renke He studied how T cells, a core part of the immune system, change their gene activity with age. Old T cells lose range and strength, which weakens defense in later life. The team used gene data from single cells and from bulk samples across healthy age groups.
Young T cells were run by one set of gene switches, and old ones by another. A growth signal path called TGF-beta stood out, with several of its parts turned up in worn-out memory T cells. The authors name these parts as possible markers of immune aging. The work may guide ways to slow that decline.
Catalog record
| CREATOR | Renke He, Chanchan Xiao, Wen Lei, Guobing Chen, Yangqiu Li, Oscar Junhong Luo |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 68 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |