Cerebral blood flow, autoregulation and vascular reactivity in normal pressure hydrocephalus: a systematic review
Afroditi Despoina Lalou, Zofia Helena Czosnyka, Marek Czosnyka, John Douglas Pickard · 2025
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Description
Afroditi Despoina Lalou and co-authors update a landmark review on blood flow and pressure control in normal pressure hydrocephalus, in a 2025 systematic review. This condition is one of few reversible causes of gait and memory decline in older adults. Shunt surgery helps selected patients, but selection is hard. Circulation may hold the missing clues.
The review asks whether flow changes are specific to the disease. It checks coupling between flow and brain metabolism. It tests whether flow predicts benefit from spinal fluid drainage. Pressure self-regulation and vessel reactivity enter as candidate predictors. The synthesis updates the field's 2001 assessment. Clinicians weighing shunt surgery gain sharper evidence. Researchers see which measurements deserve trials.
Catalog record
| CREATOR | Afroditi Despoina Lalou, Zofia Helena Czosnyka, Marek Czosnyka, John Douglas Pickard |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 92 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |