Role of gut microbiota metabolites against vein graft restenosis: insights from network pharmacology, molecular docking and molecular dynamic simulation
Zi’ang Li, Xiankun Liu, Yiming Bai, Yunpeng Bai, Zhigang Guo · 2025
Read Role of gut microbiota metabolites against vein graft restenosis: insights from network pharmacology, molecular docking and molecular dynamic simulation by Zi’ang Li, Xiankun Liu, Yiming Bai, Yunpeng Bai, Zhigang Guo (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12821893.txt.
Description
Zi'ang Li and four co-authors shared a study in twenty twenty-five. They asked if products made by gut microbes could fight a known risk. The risk is the re-narrowing of vein grafts after bypass surgery. The idea is new ground. Metabolites made by gut bacteria travel through the body. They tune inflammation as they go. The team took on the question in silico, with no lab work.
Databases gave them gut microbes, the metabolites those microbes make, and human targets. They matched predicted metabolite targets with disease genes. The shared set formed a network. It showed hub molecules and hub microbes. Docking simulations and dynamic modeling tested the grip of the top metabolites on their targets. Drug-likeness and toxicity screens ran at the same time. The study gives ranked candidates for lab follow-up. It is not yet proof of effect.
Catalog record
| CREATOR | Zi’ang Li, Xiankun Liu, Yiming Bai, Yunpeng Bai, Zhigang Guo |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 50 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |