Senescence-driven molecular subtyping in pancreatic cancer: a multi-omics framework for precision medicine
Meilong Shi, Penghao Li, Bo Li, Huan Wang, Xiaoyi Yin, Xiaohan Shi, Suizhi Gao, Yikai Li, Chuanqi Teng, Shuai Yuan, Xinyu Liu, Zhendong Fu, Xiaochao Kang, Wei Jin, Bin Song, Kailian Zheng, Yijie Zhang, Xiongfei Xu, Shiwei Guo, Gang Jin · 2025
Read Senescence-driven molecular subtyping in pancreatic cancer: a multi-omics framework for precision medicine by Meilong Shi, Penghao Li, Bo Li, Huan Wang, Xiaoyi Yin, Xiaohan Shi, Suizhi Gao, Yikai Li, Chuanqi Teng, Shuai Yuan, Xinyu Liu, Zhendong Fu, Xiaochao Kang, Wei Jin, Bin Song, Kailian Zheng, Yijie Zhang, Xiongfei Xu, Shiwei Guo, Gang Jin (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12821805.txt.
Description
Meilong Shi and co-authors sort pancreatic tumors into three types based on genes tied to cell aging, in a 2025 study. Pancreatic cancer is among the deadliest cancers, and its variety helps it evade treatment. Cell aging programs shape how tumors grow and respond, yet their pancreas-specific role in sorting tumors was untested.
Using several kinds of molecular data from hundreds of aging-linked genes, the team found three groups: one rich in immune cells, one in between, and one rewired for fuel use. The fuel-driven group responded in lab screens to two existing drugs, and a twenty-gene test could tell the groups apart with high accuracy. The authors propose matching treatment to type.
Catalog record
| CREATOR | Meilong Shi, Penghao Li, Bo Li, Huan Wang, Xiaoyi Yin, Xiaohan Shi, Suizhi Gao, Yikai Li, Chuanqi Teng, Shuai Yuan, Xinyu Liu, Zhendong Fu, Xiaochao Kang, Wei Jin, Bin Song, Kailian Zheng, Yijie Zhang, Xiongfei Xu, Shiwei Guo, Gang Jin |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 55 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |