Consequences of Hypoxic Events, Necrosis, and Microvascular Density, in Astrocytoma IDH-Mutant, CNS WHO Grade 4
Cristian Ionut Orasanu, Madalina Bosoteanu, Sorin Vamesu, Raluca Ioana Voda, Anamaria Sincu, Mariana Deacu · 2025
Read Consequences of Hypoxic Events, Necrosis, and Microvascular Density, in Astrocytoma IDH-Mutant, CNS WHO Grade 4 by Cristian Ionut Orasanu, Madalina Bosoteanu, Sorin Vamesu, Raluca Ioana Voda, Anamaria Sincu, Mariana Deacu (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12821448.txt.
Description
Cristian Ionut Orasanu and co-authors asked which features of a fierce brain tumor foretell a patient's course, in a 2025 study. The tumor is a grade 4 astrocytoma with a mutated IDH gene, marked by dead tissue and dense new blood vessels. Over ten years the team gathered forty-four cases, read their scans and slides, and measured how much of each tumor was dead and how dense its vessels were. Six protein stains and gene tests filled out the picture.
Older age, high blood pressure, diabetes, and sudden symptom onset all tracked with worse outcomes. More complete surgical removal protected patients, while leftover tumor hurt. Dead tissue share and vessel density themselves predicted shorter survival. So did an overactive p53 protein, loss of the PTEN gene, and changes in the CDKN2A gene. The authors say oxygen-starved, vessel-rich tumors are the aggressive ones to watch.
Catalog record
| CREATOR | Cristian Ionut Orasanu, Madalina Bosoteanu, Sorin Vamesu, Raluca Ioana Voda, Anamaria Sincu, Mariana Deacu |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |