Effects of penehyclidine hydrochloride on postoperative nausea and vomiting in patients who underwent radical thoracoscopic lung cancer surgery: study protocol for a single-center, prospective, randomized controlled clinical trial
Ni Wang, Shu-hui Hou, Rui Meng, Yi-Bao Zhang, Ying-Chun Guo, Wei Zhong, Gao-Yuan Xi, Jun-Hui Zhou, Zhi-bin Lang · 2025
Read Effects of penehyclidine hydrochloride on postoperative nausea and vomiting in patients who underwent radical thoracoscopic lung cancer surgery: study protocol for a single-center, prospective, randomized controlled clinical trial by Ni Wang, Shu-hui Hou, Rui Meng, Yi-Bao Zhang, Ying-Chun Guo, Wei Zhong, Gao-Yuan Xi, Jun-Hui Zhou, Zhi-bin Lang (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12821310.txt.
Description
Ni Wang and co-authors lay out a trial testing whether an old-style drug can spare lung cancer patients a miserable side effect of surgery. Their 2025 protocol targets nausea and vomiting after keyhole removal of lung tumors, a problem that delays recovery and raises costs. The drug, penehyclidine hydrochloride, blocks selected receptors and may calm surgery-related reactions.
The single-center trial will enroll 446 patients, split evenly between drug and saline placebo, with staff and patients blinded. Doses come before anesthesia and again across the two days after surgery. The main yardstick is nausea and vomiting within the first day; secondary checks track severity by time window, satisfaction scores, and side effects like dry mouth and dizziness. As a protocol, the paper's value is its design discipline: outcomes, timing, and analysis plans fixed before the first patient is treated.
Catalog record
| CREATOR | Ni Wang, Shu-hui Hou, Rui Meng, Yi-Bao Zhang, Ying-Chun Guo, Wei Zhong, Gao-Yuan Xi, Jun-Hui Zhou, Zhi-bin Lang |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |