LAMC2 promotes gallbladder carcinoma metastasis through the TGF-β pathway
Mengyou Xu, Yuanyuan Zhang, Huibo Feng, Taiyu Shang, Yibin Chen, Erdong Liu, Yunkai Lin, Yufei Pan, Yanan Zhou, Xiaofan Feng, Liwei Dong, Tianyi Jiang, Hongyang Wang · 2025
Read LAMC2 promotes gallbladder carcinoma metastasis through the TGF-β pathway by Mengyou Xu, Yuanyuan Zhang, Huibo Feng, Taiyu Shang, Yibin Chen, Erdong Liu, Yunkai Lin, Yufei Pan, Yanan Zhou, Xiaofan Feng, Liwei Dong, Tianyi Jiang, Hongyang Wang (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12821298.txt.
Description
Mengyou Xu and twelve co-authors study a protein in gallbladder cancer in a paper from two thousand twenty-five. The cancer is aggressive and often fatal, and the protein LAMC2 has aided growth and drug resistance in other cancers. Its role in gallbladder cancer was unclear.
Tumor tissue showed high LAMC2 levels, tied to worse patient outcomes. Silencing the gene in cells cut colony growth, sphere formation, and spread, and it reversed a shift linked to metastasis. The same held in organoids and an animal spread model. A signaling pathway both switched the gene on and was boosted by its product, forming a feedback loop. The authors propose LAMC2 as a marker and drug target.
Catalog record
| CREATOR | Mengyou Xu, Yuanyuan Zhang, Huibo Feng, Taiyu Shang, Yibin Chen, Erdong Liu, Yunkai Lin, Yufei Pan, Yanan Zhou, Xiaofan Feng, Liwei Dong, Tianyi Jiang, Hongyang Wang |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 49 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |