Pre-eclampsia-related TLR2/4 signaling activates NOX2/4 to induce oxidative stress and ferroptosis in trophoblasts
Yan Zhang, Yunmei Ke, Baosheng Zhu, Zhuo Chen, Li Ren, Jinman Zhang, Jie Wu · 2025
Read Pre-eclampsia-related TLR2/4 signaling activates NOX2/4 to induce oxidative stress and ferroptosis in trophoblasts by Yan Zhang, Yunmei Ke, Baosheng Zhu, Zhuo Chen, Li Ren, Jinman Zhang, Jie Wu (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12821286.txt.
Description
Yan Zhang and co-authors study a chain of signals that harms placenta cells in pre-eclampsia, a dangerous pregnancy condition, in work from 2025. Oxidative stress and a form of iron driven cell death are known to hurt the cells that feed the growing baby. The team asked whether immune sensor proteins drive that harm.
Placenta tissue from twenty patients and twenty healthy controls was tested for the sensors and related signals. Placenta like cells were put through low oxygen cycles to mimic the disease. Tests covered growth, movement, invasion, and tube forming. Death and stress markers rose with the signal chain. Blocking it is proposed as a treatment path.
Catalog record
| CREATOR | Yan Zhang, Yunmei Ke, Baosheng Zhu, Zhuo Chen, Li Ren, Jinman Zhang, Jie Wu |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |