The complement cascade in Alzheimer’s disease: modern implications of an ancient immune protagonist
Maria-Tzousi Papavergi, Praveen Bathini, Brijendra Singh, Cynthia A. Lemere · 2025
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Description
Maria-Tzousi Papavergi and co-authors review the complement cascade as an old immune arm turned foe in Alzheimer's disease. Their 2025 paper traces how this blood-born defense, vital for pruning synapses as the brain grows, can reignite in aging and eat synapses instead. In Alzheimer's and its vessel cousin, stray complement feeds plaque growth, synapse loss, swelling, and barrier leaks.
The review runs from human finds to animal models and stem-cell-grown brain cells. Genes, gene switches, and gut signals tune the cascade. Blood marks of its firing and drugs that block its parts close the tour.
Catalog record
| CREATOR | Maria-Tzousi Papavergi, Praveen Bathini, Brijendra Singh, Cynthia A. Lemere |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 120 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |