Tetrabenazine-induced miR-34a-5p suppresses the tumorigenicity of radioresistant colorectal cancer by inhibiting M2 macrophage polarization
Dong Hyeon Lee, Hyun Jeong Seok, Jae Yeon Choi, Junhye Kwon, Ui Sup Shin, In Hwa Bae · 2025
Read Tetrabenazine-induced miR-34a-5p suppresses the tumorigenicity of radioresistant colorectal cancer by inhibiting M2 macrophage polarization by Dong Hyeon Lee, Hyun Jeong Seok, Jae Yeon Choi, Junhye Kwon, Ui Sup Shin, In Hwa Bae (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12821203.txt.
Description
Dong Hyeon Lee and co-authors test an approved drug as a weapon against treatment-resistant colorectal cancer, in a study from 2025. Radiation often fails when cancer cells resist it, so new options are needed. The team screened a library of approved drugs for one that could curb resistant cells.
The drug tetrabenazine, long used for excess movement disorders, stood out. In resistant cells, it cut the drivers of a shape shift that helps cancer spread, acting through a p53 and microRNA path. It slowed cell migration and invasion more than a standard drug did. The induced microRNA also curbed a macrophage state that feeds tumors, lowering its IL-10 output. Checks on patient samples backed the lab findings.
Catalog record
| CREATOR | Dong Hyeon Lee, Hyun Jeong Seok, Jae Yeon Choi, Junhye Kwon, Ui Sup Shin, In Hwa Bae |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 52 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |