A Case of Metastatic Renal Cell Carcinoma Developing Isolated Adrenocorticotropic Hormone (ACTH) Deficiency During Nivolumab Therapy
Michihiro Enoki, Kazuaki Yamanaka, Atsunari Kawashima, Shinichiro Fukuhara, Norio Nonomura · 2025
Read A Case of Metastatic Renal Cell Carcinoma Developing Isolated Adrenocorticotropic Hormone (ACTH) Deficiency During Nivolumab Therapy by Michihiro Enoki, Kazuaki Yamanaka, Atsunari Kawashima, Shinichiro Fukuhara, Norio Nonomura (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12820900.txt.
Description
Michihiro Enoki and co-authors report a kidney cancer patient whose hormone control failed during immune therapy, in this 2025 case report. The patient, treated with nivolumab for cancer spread to pancreas and thyroid, developed isolated ACTH deficiency, where the pituitary gland stops signaling the adrenal glands. The vague symptoms cleared once the drug stopped and daily hormone replacement began.
The patient still needs daily steroids to stay well. Yet the cancer has stayed in partial retreat for over four years since the drug was stopped. The authors stress spotting immune hormone side effects early.
Catalog record
| CREATOR | Michihiro Enoki, Kazuaki Yamanaka, Atsunari Kawashima, Shinichiro Fukuhara, Norio Nonomura |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 9 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |