Protease profiling in fecal samples: a novel non-invasive diagnostic tool for gastrointestinal disorders
Laura Baldassar, Laura Cendron, Sonia Facchin, Carlo Redavid, Brigida Barberio, Alireza Jorkesh, Monica Dettin, Antonella Pasquato, Edoardo Vincenzo Savarino · 2025
Read Protease profiling in fecal samples: a novel non-invasive diagnostic tool for gastrointestinal disorders by Laura Baldassar, Laura Cendron, Sonia Facchin, Carlo Redavid, Brigida Barberio, Alireza Jorkesh, Monica Dettin, Antonella Pasquato, Edoardo Vincenzo Savarino (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12820393.txt.
Description
Laura Baldassar and co-authors report a 2025 study on reading enzyme activity in stool as a non-invasive way to sort gut disorders. Bowel inflammation diseases and irritable bowel syndrome share signs but split in cause and care. The team ran stool samples across a custom panel of glow-tagged test strings at varied acid levels.
Samples from inflamed bowel patients showed broad enzyme firing across two enzyme families. The small irritable bowel group leaned toward one enzyme family's pattern, strongest at the alkaline end. One test string split the two inflamed types at acid levels with fair sorting power. Block tests proved the enzyme role. Even in quiet-phase patients, the off-pattern held, hinting at a mark that outlasts flares.
Catalog record
| CREATOR | Laura Baldassar, Laura Cendron, Sonia Facchin, Carlo Redavid, Brigida Barberio, Alireza Jorkesh, Monica Dettin, Antonella Pasquato, Edoardo Vincenzo Savarino |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |