Natural talc: a basic, cost-effective, and available catalyst for the one-pot synthesis of dihydropyranochromenes and pyranopyrazoles, along with related DFT calculations
Abolfazl Dehghanizadeh, Bi Bi Fatemeh Mirjalili, Hadi Basharnavaz · 2025
Read Natural talc: a basic, cost-effective, and available catalyst for the one-pot synthesis of dihydropyranochromenes and pyranopyrazoles, along with related DFT calculations by Abolfazl Dehghanizadeh, Bi Bi Fatemeh Mirjalili, Hadi Basharnavaz (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12820251.txt.
Description
Abolfazl Dehghanizadeh, Bi Bi Fatemeh Mirjalili, and Hadi Basharnavaz cook up two useful ring-shaped drug building blocks with plain talc powder as the helper. Drug chemists prize these oxygen-rich rings, but many routes to them need harsh or costly catalysts. Talc is cheap, mild, safe, and easy to find.
One family of rings was made in hot ethanol with talc; the other was made with no solvent at all, just mixing. Both gave yields above ninety-five percent. Tests confirmed the products were what the team aimed for. Computer work on the products' energy gaps adds a guide for future tweaks. The authors pitch talc as a green stand-in for pricier catalysts.
Catalog record
| CREATOR | Abolfazl Dehghanizadeh, Bi Bi Fatemeh Mirjalili, Hadi Basharnavaz |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 20 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |