Hypoxic BMSC-derived exosomes-induced mitophagy quenches intestinal inflammation via HIF-1α/BNIP3 pathway
Feng Zhu, Jingbo Wang, Yuyi Yuan, Chunzhu Wei, Fei Gao, Xingxing Liu, Jingjing Li, Zaifeng Yi, Lijuan Zhang, Heng Fan · 2025
Read Hypoxic BMSC-derived exosomes-induced mitophagy quenches intestinal inflammation via HIF-1α/BNIP3 pathway by Feng Zhu, Jingbo Wang, Yuyi Yuan, Chunzhu Wei, Fei Gao, Xingxing Liu, Jingjing Li, Zaifeng Yi, Lijuan Zhang, Heng Fan (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12820211.txt.
Description
Feng Zhu and co-authors test stem cell vesicles against ulcerative colitis in a 2025 study. Tiny exosomes from bone marrow stem cells, grown under low oxygen, may calm intestinal immunity. How the low-oxygen preparation changes the vesicles and how they act in colitis were not adequately understood.
The team isolated and characterized the vesicles, then studied their effects. The vesicles triggered mitophagy, the recycling of damaged mitochondria, through a pathway involving two named proteins. Clearing damaged mitochondria in gut cells eased inflammation, pointing to a cell-free therapy route for a hard bowel disease.
Catalog record
| CREATOR | Feng Zhu, Jingbo Wang, Yuyi Yuan, Chunzhu Wei, Fei Gao, Xingxing Liu, Jingjing Li, Zaifeng Yi, Lijuan Zhang, Heng Fan |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |