Early favorable prostate-specific antigen response prediction in metastatic hormone sensitive prostate cancer
Soumyajit Roy, Yilun Sun, Maha Hussain, Kim N. Chi, Karim Fizazi, Ian D. Davis, Susan Halabi, Neeraj Agarwal, Simon Chowdhury, Bertrand Tombal, Scott C. Morgan, Shawn Malone, Pedro C. Barata, Michael Ong, Christopher J. D. Wallis, Alejandro Berlin, Umang Swami, Amar U. Kishan, Angela Y. Jia, Nichola · 2025
Read Early favorable prostate-specific antigen response prediction in metastatic hormone sensitive prostate cancer by Soumyajit Roy, Yilun Sun, Maha Hussain, Kim N. Chi, Karim Fizazi, Ian D. Davis, Susan Halabi, Neeraj Agarwal, Simon Chowdhury, Bertrand Tombal, Scott C. Morgan, Shawn Malone, Pedro C. Barata, Michael Ong, Christopher J. D. Wallis, Alejandro Berlin, Umang Swami, Amar U. Kishan, Angela Y. Jia, Nichola (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12819402.txt.
Description
Soumyajit Roy and co-authors build a prediction tool for prostate cancer care in a 2025 paper. The setting is metastatic hormone-sensitive prostate cancer, treated with modern hormone-blocking drugs. A deep early drop in the PSA blood marker signals a good response, but doctors cannot tell in advance who will get one. The team trained a statistical model on patients from three large trials.
The locked model was then tested on patients from a fourth trial treated with a different drug of the same class. It sorted patients well: top-third predictions responded over ninety percent of the time, while bottom-third predictions responded under forty percent. The authors say that, pending prospective checks, such a tool could guide early treatment choices and spare poor candidates false hope.
Catalog record
| CREATOR | Soumyajit Roy, Yilun Sun, Maha Hussain, Kim N. Chi, Karim Fizazi, Ian D. Davis, Susan Halabi, Neeraj Agarwal, Simon Chowdhury, Bertrand Tombal, Scott C. Morgan, Shawn Malone, Pedro C. Barata, Michael Ong, Christopher J. D. Wallis, Alejandro Berlin, Umang Swami, Amar U. Kishan, Angela Y. Jia, Nichola |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |