Antimalarial potential of curcumin derivatives evaluated through experimental and computational approaches
Siti Nur Hidayah Jamil, Khairul Azreena Bakar, Amatul Hamizah Ali, Nur Fatin Najihah Marzuki, Fatima Shahid, Fauze Mahmud, Shevin Rizal Feroz, Su Datt Lam, Natsuhisa Oka, Yusmazura Zakaria, Muhamad Imam Muhajir, Rani Maharani, Unang Supratman, Jalifah Latip · 2025
Read Antimalarial potential of curcumin derivatives evaluated through experimental and computational approaches by Siti Nur Hidayah Jamil, Khairul Azreena Bakar, Amatul Hamizah Ali, Nur Fatin Najihah Marzuki, Fatima Shahid, Fauze Mahmud, Shevin Rizal Feroz, Su Datt Lam, Natsuhisa Oka, Yusmazura Zakaria, Muhamad Imam Muhajir, Rani Maharani, Unang Supratman, Jalifah Latip (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12819389.txt.
Description
Siti Nur Hidayah Jamil and co-authors test altered forms of curcumin, the yellow compound in turmeric, as possible malaria drugs. Malaria still kills many people each year, and drug resistance keeps weakening current cures. Curcumin itself is poorly absorbed by the body. Their 2025 study makes ten altered versions and tests them in dishes and on computers.
Most new versions beat plain curcumin against two malaria parasite strains, including a drug-resistant one. The best compound also blocked a human enzyme target in a selective way. Computer models showed good binding and better drug-like traits than curcumin. The compounds also grab onto a blood pigment the parasite produces, which may add to their punch. Safety in cells still needs work, the team note.
Catalog record
| CREATOR | Siti Nur Hidayah Jamil, Khairul Azreena Bakar, Amatul Hamizah Ali, Nur Fatin Najihah Marzuki, Fatima Shahid, Fauze Mahmud, Shevin Rizal Feroz, Su Datt Lam, Natsuhisa Oka, Yusmazura Zakaria, Muhamad Imam Muhajir, Rani Maharani, Unang Supratman, Jalifah Latip |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 63 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |