Noninvasive early diagnosis of laryngeal squamous cell carcinoma (LSCC) revealing the high-performance potential of the HOXD10 gene monomethylated locus: a case–control study
Xiaoyang Gong, Zhaoyi Lu, Zihang Zhu, Qin Zhang, Haibing Chen, Han Zhou, Qianqian Duan, Chan Zhu, Dongsheng Chen, Lei Cheng, Xin Cao, Xi Chen · 2025
Read Noninvasive early diagnosis of laryngeal squamous cell carcinoma (LSCC) revealing the high-performance potential of the HOXD10 gene monomethylated locus: a case–control study by Xiaoyang Gong, Zhaoyi Lu, Zihang Zhu, Qin Zhang, Haibing Chen, Han Zhou, Qianqian Duan, Chan Zhu, Dongsheng Chen, Lei Cheng, Xin Cao, Xi Chen (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12817775.txt.
Description
Cancer of the larynx is often found late because there is no easy, gentle test for it. Gong and co-authors hunted for a signal in blood: chemical methylation marks on DNA that differ between tumor and healthy tissue. Mining public databases, they found one spot in the HOXD10 gene that was heavily methylated in tumors, then checked it in blood from forty-three patients and fifty healthy controls.
The mark separated patients from controls with fair accuracy overall. It did best exactly where it matters most, in stage one disease, where it reached higher sensitivity and specificity than in the full patient group. The authors present the locus as the first blood-based methylation marker shown for this cancer. They frame it as a candidate for a noninvasive early test, pending wider validation.
Catalog record
| CREATOR | Xiaoyang Gong, Zhaoyi Lu, Zihang Zhu, Qin Zhang, Haibing Chen, Han Zhou, Qianqian Duan, Chan Zhu, Dongsheng Chen, Lei Cheng, Xin Cao, Xi Chen |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |