Beyond the label: ethical and clinical implications of off-label drug use in pediatric emergency care
Marco Colombo, Anna Plebani, Massimo Agosti · 2025
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Description
Marco Colombo, Anna Plebani, and Massimo Agosti examine off label drug use in children's emergency care, where medicines are routinely given outside their approved uses. Published in 2025, the article explains the drivers: trials in children are scarce, approvals lag, and a crashing child cannot wait. The practice can save lives, and it can also outrun the evidence.
A case study walks through one real decision and its tangles. Consent, legal exposure, and uneven dosing data all press on the clinician at once. The authors ask for sharper consent routines, stronger after market surveillance, and guidelines built for the emergency setting. Their aim is not to ban the practice but to fence it with evidence.
Catalog record
| CREATOR | Marco Colombo, Anna Plebani, Massimo Agosti |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 16 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |