The clinical features and outcome of Kawasaki disease combined with G6PD deficiency
Peisi Cheng, Tingyan He, Jun Yang · 2025
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Description
Kawasaki disease inflames children's blood vessels, and some patients also lack the enzyme G6PD, which changes which drugs are safe. The three authors run a retrospective case-control study: 54 Kawasaki patients with the deficiency against 162 matched patients with normal enzyme activity. They compare symptoms, risk class, and lasting coronary artery lesions, and they note the deficient group was managed without aspirin.
Symptoms and lab values looked similar in both groups. The deficiency tied to a high-risk label under the SANO criteria but not under other criteria, hinting those criteria misfit this subgroup. Lasting artery lesions after eight weeks were not significantly different, 12.77 against 6.21 percent, and IVIG resistance was comparable. The authors conclude the deficiency is probably not a real risk factor for artery lesions, and skipping aspirin did not clearly harm short-term outcomes.
Catalog record
| CREATOR | Peisi Cheng, Tingyan He, Jun Yang |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 29 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |