A novel tRF-Gly is associated with obesity development through post-transcriptional regulation of lipid metabolism
Yuhang Lei, Mailin Gan, Kai Wang, Tianci Liao, Yiting Yang, Xue Zhao, Xin Zhang, Dujun Chen, Xinyi Wang, Jianfeng Ma, Lili Niu, Ye Zhao, Lei Chen, Xiaofeng Zhou, Yan Wang, Mingzhou Li, Li Zhu, Linyuan Shen · 2025
Read A novel tRF-Gly is associated with obesity development through post-transcriptional regulation of lipid metabolism by Yuhang Lei, Mailin Gan, Kai Wang, Tianci Liao, Yiting Yang, Xue Zhao, Xin Zhang, Dujun Chen, Xinyi Wang, Jianfeng Ma, Lili Niu, Ye Zhao, Lei Chen, Xiaofeng Zhou, Yan Wang, Mingzhou Li, Li Zhu, Linyuan Shen (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12817741.txt.
Description
Yuhang Lei and co-authors finger a tiny RNA fragment, broken off a transfer RNA, as a lever on fat growth. Obesity's roots run deeper than calories, into the small regulatory RNAs that tune metabolism gene by gene. Sequencing visceral fat from obese and lean pigs surfaced one fragment, tRF-Gly, abundant in the obese animals.
Functional experiments followed the candidate into fat cells, testing how it steers lipid metabolism after transcription. Pigs, whose fat biology mirrors ours more closely than mice, make the finding translationally suggestive. Every newly proven molecular handle on adipocyte behavior is a possible drug target in a crisis short on safe, durable treatments.
Catalog record
| CREATOR | Yuhang Lei, Mailin Gan, Kai Wang, Tianci Liao, Yiting Yang, Xue Zhao, Xin Zhang, Dujun Chen, Xinyi Wang, Jianfeng Ma, Lili Niu, Ye Zhao, Lei Chen, Xiaofeng Zhou, Yan Wang, Mingzhou Li, Li Zhu, Linyuan Shen |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 67 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |