Metabolic-transcriptional rewiring by NFE2L2 promotes M2 macrophage polarization and anti-PD-L1 resistance in glioma
Qiusi Tian, Qun Zhang, Rongzhen Deng, Shengnan Dong, Zhijun Bao, Qingjuan Chen · 2025
Read Metabolic-transcriptional rewiring by NFE2L2 promotes M2 macrophage polarization and anti-PD-L1 resistance in glioma by Qiusi Tian, Qun Zhang, Rongzhen Deng, Shengnan Dong, Zhijun Bao, Qingjuan Chen (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12817732.txt.
Description
Six researchers report a brain tumor study from two thousand twenty-five on why some tumors resist immune therapy. The tumor is glioma, a highly malignant brain cancer. Its surroundings shut down immune attack, and that trait tracks with poor outcomes for patients.
The team studied a gene switch called NFE2L2, which runs high in glioma tissue. High levels went with more immune cells of a type that shields the tumor. Raising the switch in cells made tumor cells move and invade more. In mice built to lack the switch, the picture changed. The work ties the switch to drug resistance against a common immune therapy.
Catalog record
| CREATOR | Qiusi Tian, Qun Zhang, Rongzhen Deng, Shengnan Dong, Zhijun Bao, Qingjuan Chen |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |