Validation of a model of rheumatoid arthritis using mice reconstituted with patient peripheral blood mononuclear cells
Paula Schuster-Winkelmann, Veronika Weß, Marietta Schindler, Morten Ø. Jensen, David E. Shaw, Paolo Alberton, Hendrik Schulze-Koops, Silvia Schoenthaler, Andreas Weinhaeusel, Matthias Siebeck, Roswitha Gropp, Attila Aszodi · 2025
Read Validation of a model of rheumatoid arthritis using mice reconstituted with patient peripheral blood mononuclear cells by Paula Schuster-Winkelmann, Veronika Weß, Marietta Schindler, Morten Ø. Jensen, David E. Shaw, Paolo Alberton, Hendrik Schulze-Koops, Silvia Schoenthaler, Andreas Weinhaeusel, Matthias Siebeck, Roswitha Gropp, Attila Aszodi (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12817335.txt.
Description
Paula Schuster-Winkelmann and co-authors test a mouse model that carries human immune cells from arthritis patients. Their 2025 paper tackles rheumatoid arthritis, a long-term disease in which the immune system attacks the joints. Human forms of the disease vary a lot, which makes animal models hard to trust.
The team placed blood cells from patients into mice with weak immune systems. They then triggered disease signs with a bacterial product and antibodies. The mice showed joint swelling, bone loss, human autoantibodies, and gene activity in known disease pathways. Two common arthritis drugs eased the signs and lowered inflammation marks. The model gives drug researchers a closer stand-in for human disease than standard mouse models.
Catalog record
| CREATOR | Paula Schuster-Winkelmann, Veronika Weß, Marietta Schindler, Morten Ø. Jensen, David E. Shaw, Paolo Alberton, Hendrik Schulze-Koops, Silvia Schoenthaler, Andreas Weinhaeusel, Matthias Siebeck, Roswitha Gropp, Attila Aszodi |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 57 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |