A machine learning-based framework for prognostic prediction and tumor microenvironment characterization of locally advanced cervical cancer with concurrent chemoradiotherapy
Yue Feng, Zijian Sun, Yuqiang Li, Fang Wang, Qiyang Li, Jiahui Ma, Xiaoyong Zhang, Hui Ye, Xiaojuan Lv, Zhao Wang, Lei Shi, Zhen Zhang, Jiayu Song, Tao Feng, Haowen Li, Chunwei Xu, Yihan Wang, Jingkui Tian, Yunyan Zhang, Liting Shi, Hanmei Lou, Wei Zhu · 2025
Read A machine learning-based framework for prognostic prediction and tumor microenvironment characterization of locally advanced cervical cancer with concurrent chemoradiotherapy by Yue Feng, Zijian Sun, Yuqiang Li, Fang Wang, Qiyang Li, Jiahui Ma, Xiaoyong Zhang, Hui Ye, Xiaojuan Lv, Zhao Wang, Lei Shi, Zhen Zhang, Jiayu Song, Tao Feng, Haowen Li, Chunwei Xu, Yihan Wang, Jingkui Tian, Yunyan Zhang, Liting Shi, Hanmei Lou, Wei Zhu (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12816678.txt.
Description
Feng and co-authors report a 2025 study that predicts outcomes for locally advanced cervical cancer treated with combined chemo and radiation. Knowing who will do well shapes treatment choices for each patient. Their framework pairs a deep learning model that reads MRI scans with protein data from tumor samples. The scan model works on images taken before treatment starts.
The model split patients into high-risk and low-risk groups and beat standard clinical factors at the task. Its scores held up in training and in two test groups, though with lower accuracy outside the home set. Protein profiles showed that high-risk tumors had a suppressed immune setting. The work links scan traits to tumor biology for better risk sorting.
Catalog record
| CREATOR | Yue Feng, Zijian Sun, Yuqiang Li, Fang Wang, Qiyang Li, Jiahui Ma, Xiaoyong Zhang, Hui Ye, Xiaojuan Lv, Zhao Wang, Lei Shi, Zhen Zhang, Jiayu Song, Tao Feng, Haowen Li, Chunwei Xu, Yihan Wang, Jingkui Tian, Yunyan Zhang, Liting Shi, Hanmei Lou, Wei Zhu |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 54 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |