Plasma cell-free DNA methylation-based prognosis in metastatic castrate-resistant prostate cancer
Jodie Wong, Yijun Tian, Manishkumar S. Patel, Kapil Avasthi, Claire Hanson, Matt Larsen, Enos Ampaw, Rebekah Gutowski, Muhammad Z. H. Fadlullah, Joseph Finkelstein, Aik Choon Tan, Jong Park, Brandon J. Manley, Chiang-Ching Huang, Manish Kohli, Liang Wang · 2025
Read Plasma cell-free DNA methylation-based prognosis in metastatic castrate-resistant prostate cancer by Jodie Wong, Yijun Tian, Manishkumar S. Patel, Kapil Avasthi, Claire Hanson, Matt Larsen, Enos Ampaw, Rebekah Gutowski, Muhammad Z. H. Fadlullah, Joseph Finkelstein, Aik Choon Tan, Jong Park, Brandon J. Manley, Chiang-Ching Huang, Manish Kohli, Liang Wang (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12816654.txt.
Description
Wong and co-authors build a blood based score to predict survival in advanced prostate cancer that no longer responds to hormone care. Doctors lack trusted markers for this stage, so forecasts are hard. Their 2025 study uses tiny DNA fragments floating in blood and marks carried on them.
The team sequenced samples from 96 patients at varied stages of the disease. They found 77 DNA blocks whose marks differed as cancer advanced, and the top 20 tracked with survival. A chart that merges the new score with standard clinical facts and tumor DNA share predicted survival well. Scores were strongest for the six month horizon and stayed solid out to two years.
Catalog record
| CREATOR | Jodie Wong, Yijun Tian, Manishkumar S. Patel, Kapil Avasthi, Claire Hanson, Matt Larsen, Enos Ampaw, Rebekah Gutowski, Muhammad Z. H. Fadlullah, Joseph Finkelstein, Aik Choon Tan, Jong Park, Brandon J. Manley, Chiang-Ching Huang, Manish Kohli, Liang Wang |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 61 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |